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IDEIA™ PASTEURELLA MULTOCIDA TOXIN EIA KIT (PMT)

Code: K000921

Introduction
PMT EIA is designed for the detection of Pasteurella multocida toxin: the causal factor of progressive atrophic rhinitis in pigs.

This kit will perform 960 tests

Principle of the Test
PMT EIA is designed for the detection of Pasteurella multocida toxin: the causal factor of progressive atrophic rhinitis in pigs.
Progressive atrophic rhinitis is a disease of pigs, caused by infection with toxigenic Pasteurella multocida.  Pathogenesis of the disease is linked to a single, well-characterised component: the Pasteurella multocida toxin (PMT). Other names for the PMT include dermonecrotic toxin (DNT); heat labile toxin (HLT); turbinate atrophy toxin (TAT) and osteolytic toxin. The clinical manifestations of the disease are shortening or distortion of the snout, sneezing, nasal discharge and epitaxis. Reduced growth rate is seen in severe cases. Subclinical forms of the disease also occur.
Host factors as well as other determinants – infectious or non-infectious – may influence the course of infection with toxigenic Pasteurella multocida. An important predisposing factor is infection with Bordetella bronchiseptica. Factors such as climate, housing and environment may influence the severity of infection as well as the persistence of toxigenic Pasteurella multocida, and thus, the clinical and economic burdens of the disease.
Health monitoring programmes should be based on laboratory tests for demonstration of toxigenic strains of Pasteurella multocida combined with clinical inspections of herds and snout sections at slaughter. The traditional laboratory tests are based on demonstration of the biological activitiy of toxin obtained from pure cultures of Pasteurella multocida. One of the main advantages of the PMT EIA is that it assures a specific and sensitive demonstration of PMT in any type of sample, including extracts of primary mixed cultures obtained from e.g. nasal swabs or washings.