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IMAGEN™ RESPIRATORY SYNCYTIAL VIRUS (RSV)

Code: K610211

Introduction
IMAGEN™ Respiratory Syncytial Virus (RSV) is a qualitative immunofluorescence test for the direct detection of RSV

50 tests

Principle of the Test
IMAGEN™ Respiratory Syncytial Virus (RSV) is a qualitative immunofluorescence test for the direct detection of RSV in clinical specimens.
RSV is an enveloped, spherical, RNA virus of the family Paramyxoviridae and is classified in the genus Pneumovirus. This genus has four members: human RSV, bovine RSV, pneumonia virus of mice and turkey rhinotracheitis virus. RSV is the major cause of lower respiratory tract disease in infants and young children causing seasonal epidemics of respiratory illness each year.
RSV is spread by virus-laden droplets of respiratory secretions from infected individuals. Infection may manifest as a variety of symptoms, ranging from rhinitis to pneumonia, which are influenced by factors such as the age, sex and socio-economic background of infected individuals5. Approximately 50% of infants infected during the first year of life may develop lower respiratory tract illness involving bronchitis, bronchiolitis, bronchopneumonia and croup which may require hospitalisation. Infants with underlying complications such as congenital heart disease, bronchopulmonary dysplasia and congenital or other immunodeficiencies may be susceptible to severe, sometimes life threatening, infection with RSV. Recurrent less severe infections occur in all age groups, occasionally resulting in pneumonia in children and the elderly. Co-infections of RSV with other micro-organisms may result in increased severity of respiratory disease. Outbreaks in geriatric wards have been associated with considerable morbidity and occasional mortality. Nosocomial transmission of RSV occurs in paediatric wards and nursery units resulting in prolonged hospitalisation and treatment of infected children. The laboratory diagnosis of RSV plays an important role in patient management and assists in the control of outbreaks.
IMAGEN™ RSV is a direct immunofluorescence test for the rapid detection and identification of RSV in human clinical specimens. The test utilises three monoclonal antibodies in order to detect specific structural proteins expressed in all strains of human Respiratory Syncytial Virus.