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IMAGEN™ RESPIRATORY SCREEN KIT

Code: K612011

Introduction
IMAGEN™ Respiratory Screen is a qualitative indirect immunofluorescence test for the presumptive detection of Respiratory Syncytial Virus (RSV), Influenza A and B virus, Parainfluenza virus 1, 2 and 3 and Adenovirus.

100 tests

Principle of the Test
IMAGEN™ Respiratory Screen is a qualitative indirect immunofluorescence test for the presumptive detection of Respiratory Syncytial Virus (RSV), Influenza A and B virus, Parainfluenza virus 1, 2 and 3 and Adenovirus in respiratory specimens (nasopharyngeal aspirates) and in cell cultures. The assay cannot differentiate between the viruses. Individual viruses should be further identified and confirmed using individual IMAGEN™ typing reagents.
Respiratory virus infections are associated with major outbreaks of respiratory disease throughout the world which have significant impact on world health. Viruses cause disease in all age groups but infections are most severe in infant, elderly and immunocompromised populations. Nosocomial outbreaks can occur in paediatric and geriatric wards resulting in extended hospitalisation, prolonged patient management and increased morbidity and mortality. Respiratory virus infections in infants may cause obstruction of airways and lead to respiratory distress.
The viruses mainly responsible for lower respiratory tract infection include RSV, Influenza A and B viruses, Parainfluenza virus types 1, 2 and 3 and Adenoviruses. RSV and Parainfluenza viruses occur seasonally and are major causes of lower respiratory tract disease in infants and young children. They frequently cause bronchiolitis, croup, bronchitis and occasionally pneumonia. Influenza A and B viruses cause world-wide seasonal epidemics of respiratory disease in adults and infants with a disease spectrum ranging from mild upper respiratory tract symptoms to severe pneumonia. Acute pneumonia in elderly or immunocompromised patients can be life threatening particularly when associated with secondary microbial infections. Adenovirus infections are associated with respiratory, ocular and enteric disease. Adenoviruses are reported to be responsible for 5% of acute respiratory disease in children under the age of 4 years and are a common cause of pharyngitis in young children. Rapid diagnosis of respiratory virus infections is an important aid in the management of patients, prevention and control of outbreaks and in influencing the use of antiviral therapy, particularly for Influenza A and RSV viral infections.
Immunofluorescence tests utilising specific monoclonal antibodies, are rapid and enable the quality of the specimen to be monitored. Centrifugation enhanced culture systems (shell-vials) accelerate isolation of respiratory viruses in cell culture and when used in conjunction with immunofluorescence tests enable rapid diagnosis of respiratory infection by cell culture.